Monotherapy Or Chemotherapy Adjunct: Pembrolizumab In Advanced NSCLC

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Monotherapy Or Chemotherapy Adjunct: Pembrolizumab In Advanced NSCLC Objectives To assess the effectiveness and safety of pembrolizumab monotherapy and in combination with chemotherapy in patients with advanced non–small-cell lung cancer (NSCLC).  Introduction Historically, patients with advanced NSCLC have a poor prognosis despite the use of platinum-based chemotherapy drugs. The 5-year relative survival rate of

Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy

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Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy Overview  Later-line treatments for advanced gastric cancer have always been debated. Although chemotherapy is the recommended option. For the last decade, immune checkpoint inhibitors have been used for the treatment of various malignancies. Trials have also been performed for gastric cancer. In this study, a

Sinonasal B‐cell lymphomas: A Cohort Study on Progression and Recurrence

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Sinonasal B‐cell lymphomas: A Cohort Study on Progression and Recurrence STUDY BACKGROUND Sinonasal lymphoma is a rare malignancy of rhinologic origin affecting the sinonasal region and surrounding structures. It is a type of non-Hodgkin lymphoma (NHL) comprising around 1.5% of all lymphomas and usually involves males aged between 40 and 70 years.

Platinum-Resistant Recurrent Ovarian Cancer Treatment +/- Bevacizumab

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Platinum-Resistant Recurrent Ovarian Cancer Treatment +/- Bevacizumab Overview Of The Study  The study aims to elucidate the efficacy of bevacizumab therapy in patients with platinum-resistant ovarian cancer whose disease has already progressed after bevacizumab plus chemotherapy therapy.  The study is a multicenter, open-label, phase II trial (JGOG3023).  Subjects were randomized 1:1 to single-agent

Metastatic Melanoma and Follow-Up MRI Scans

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Metastatic Melanoma and Follow-Up MRI Scans Metastatic melanoma is an aggressive tumor, which may spread to organs either by local invasion, or lymphatic or hematogenous dissemination. Central Nervous System (CNS), especially the brain, account for up to 50% of metastasis. Skin, lymph nodes, lung, and liver are other commonly involved organs,

Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia

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Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia The difficulty of making an accurate prognosis of acute T- cell lymphoblastic leukemia (T- ALL) and T- cell lymphoblastic lymphoma (T- LBL) in seniors and patients with relapsed illness has always been an issue in the medical field. Since there is no specified standard

Ocular Melanoma and Treatment with Metformin

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Ocular Melanoma and Treatment with Metformin Metformin Activity  Metformin is one of the most common medications for patients with type 2 diabetes mellitus. It is an antihyperglycemic agent that activates the adenosine monophosphate-activated kinase (AMPK). Through this, a person’s cellular ATP levels are restored. The activation of AMPK by metformin suggests that

Gastric Neuroendocrine Neoplasms

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Gastric Neuroendocrine Neoplasms Overview Gastric neuroendocrine neoplasms are rare lesions found in the stomach. They grow slowly and are often divided into four types based on their clinical characteristics. Type I lesions are found in the stomach and are linked with autoimmune chronic atrophic gastritis. Type II lesions are often caused by

Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report

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Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report Background Bipolar disorder is a multifactorial illness with uncertain etiology and geriatric new-onset manic episodes are highly associated with secondary organic causes. The presented case demonstrates the importance of excluding secondary causes during the entire disease course.  Overview Bipolar disorder is a

Anlotinib with Camrelizumab in Lung Cancer Treatment

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Anlotinib with Camrelizumab in Lung Cancer Treatment Background Checkpoint inhibitors (CPIs) and anti-angiogenic agents are emerging as potential novel treatment choices for advanced cancers including metastatic non-small-cell lung cancer (NSCLC). However, the combination of these two standard therapies has not been investigated in third-line or further-line treatment of patients with advanced NSCLC.

Monotherapy Or Chemotherapy Adjunct: Pembrolizumab In Advanced NSCLC