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Usual Dosing (Adults)

DOSAGE AND ADMINISTRATION

Fingernail onychomycosis: One 250 mg tablet once daily for 6 weeks.

Toenail onychomycosis: One 250 mg tablet once daily for 12 weeks.

The optimal clinical effect is seen some months after mycological cure and cessation of treatment. This is related to the period required for outgrowth of healthy nail.

Renal Dosing

dialysis [CRCL>50]: No changes.

[<50 ]: Manufacturer: Due to lack of data, terbinafine is not recommended in patients with CRCL <50. NO SPECIFIC RECOMMENDATIONS IN CURRENT PACKAGE INSERT.

Package insert:
In patients with renal impairment (creatinine clearance <50 mL/min) or hepatic cirrhosis, the clearance of terbinafine is decreased by approximately 50% compared to normal volunteers.

Hemodialysis

dialysis See comments above.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.
Terbinafine