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Usual Dosing (Adults)

DOSAGE AND ADMINISTRATION

The dose of KETEK tablets is 800 mg (2 tablets of 400 mg) taken orally once every 24 hours, for 7-10 days. KETEK tablets can be administered with or without food.

KETEK may be administered without dosage adjustment in the presence of hepatic impairment.

Renal Dosing

dialysis [>30 ml/min]: No Change.

[<30 ml/min]:  600 mg qd.  If concomitant hepatic impairment: 400 mg qd.

In the presence of severe renal impairment (CLCR < 30 mL/min), including patients who need dialysis, the dose should be reduced to KETEK 600 mg once daily. In patients undergoing hemodialysis, KETEK should be given after the dialysis session on dialysis days.

In the presence of severe renal impairment (CLCR < 30 mL/min), with coexisting hepatic impairment, the dose should be reduced to KETEK 400 mg once daily.

Hemodialysis

dialysis Dose as for CrCl<30, on dialysis days give dose after dialysis

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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Telithromycin