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Usual Dosing (Adults)

Ventricular arrhythmias:
Initial: 80 mg orally twice daily. Dose may be increased gradually to 240-320 mg/day - allow 3 days between dosing increments. Usual range: Most patients respond to 160-320 mg/day in 2-3 divided doses.

Renal Dosing

dialysis Ventricular arrhythmias (Betapace ®, Sorine ®):
[CRCL >60 ml/min]: Give q12h.
[30-60]: Give q24h.
[10-30]: Give q36-48 hours.
[<10]: Individualize dose.

Atrial fibrillation/flutter (Betapace AF®):
[CRCL >60 ml/min]: Give q12h.
[40-60]: Give q24h.
[<40]: Use is contraindicated.

Hemodialysis

dialysis Administer dose post-dialysis or administer supplemental 80 mg dose. Peritoneal dialysis does not remove sotalol - supplemental dose is not necessary.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.
Sotalol