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Usual Dosing (Adults)

INDICATIONS AND USAGE
RAPAFLO, an alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). RAPAFLO is not indicated for the treatment of hypertension.

DOSAGE AND ADMINISTRATION
8 mg capsules taken orally once daily with a meal.
4 mg capsules taken orally once daily with a meal for those with moderate renal impairment [Creatinine Clearance (CCr) 30-50 mL/min].

DOSAGE FORMS AND STRENGTHS
Capsules: 8 mg and 4 mg.

Renal Dosing

dialysis Renal impairment: RAPAFLO is contraindicated in patients with severe renal impairment (Creatinine Clearance - CCr < 30 mL/min). In patients with moderate renal impairment (CCr 30-50 mL/min), the dose should be reduced to 4 mg once daily taken with a meal. No dosage adjustment is needed in patients with mild renal impairment (CCr 50-80 mL/min)

 Creatinine clearance can be estimated from serum creatinine using the Cockcroft-Gault formula.

Creatinine clearance for males = [140-age (years)]× [body wt (kg)]
72 × [serum creatinine (mg/dL)]
Creatinine clearance for females = [140-age (years)]× [body wt (kg)]× 0.85
72 × [serum creatinine (mg/dL)]

Hemodialysis

dialysis RAPAFLO is contraindicated in patients with severe renal impairment (Creatinine Clearance - CCr < 30 mL/min).

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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Silodosin (Rapaflo)