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Usual Dosing (Adults)

Seizure disorders: Initial: 125-250 mg/day orally at bedtime. Increase by 125 to 250 mg/day q3-7 days. Usual dose: 750-1500 mg/day in divided doses 3-4 times/day. Maximum dosage: 2 grams/day.

Renal Dosing

dialysis [CRCL 50-80 ml/min]: give q8h

[10-50]: Give q 8-12 hours.

[ <10 ]: Give q12-24 hours.

Hemodialysis

dialysis Dose as for CrCl<10  - on dialysis days supplement with 1/3 of usual dose AD

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.
Primidone