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Usual Dosing (Adults)

Neuromuscular blockade: Initial: 0.06-0.1 mg/kg or 0.05 mg/kg after initial dose of succinylcholine for intubation; maintenance dose: 0.01 mg/kg 60-100 minutes after initial dose and then 0.01 mg/kg every 25-60 minutes.

Neuromuscular blockade in the ICU: 0.05-0.1 mg/kg bolus followed by 0.8-1.7 mcg/kg/minute once initial recovery from bolus observed or 0.1-0.2 mg/kg every 1-3 hours

Renal Dosing

dialysis Elimination half-life is doubled, plasma clearance is reduced, and rate of recovery is sometimes much slower.
[CRCL 10-50 ml/min]: Administer 50% of normal dose.
[<10 ml/min]: Do not use.

Hemodialysis

dialysis Do not use.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.
Pancuronium