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Usual Dosing (Adults)

In order to provide adequate buffering, patients must take at least 2 of the appropriate strength tablets at each dose when using either the once daily or twice daily regimens.  

Patient weight <60 kg: (Tablets): 125 mg orally twice daily or 250mg once daily or 167 mg (Buffered powder) twice daily.   

Patient weight > 60kg: (Tablets): 200mg orally twice daily or 400mg orally once daily. (Buffered Powder): 250mg orally twice daily.  

Renal Dosing

dialysis

Patients > 60 kg

  Tablets Powder
30-59 100 bid or 200mg qd 100 mg bid
10-29 150mg qd 167mg qd
<10 100mg qd 100mg qd

Patients < 60kg

Tablets Powder
30-59 75mg bid or 150mg qd 100mg bid
10-29 100 mg qd 100 mg qd
<10 75 mg qd 100mg qd

[CRCL >60]: No change.

[30-59]: (>60kg): oral tabs: 100mg bid or 200mg qd. Powder: 100mg bid. Videx EC: 200mg qd. (<60kg): 75mg bid or 150mg qd. Powder: 100mg bid. Videx EC: 125mg qd.

[10-29]: (>60kg): Tabs: 150mg qd. Powder: 167mg qd. Videx EC: 125mg qd. (<60kg): 100mg qd. Powder: 100mg qd. Videx EC: 125mg qd.

[<10 ]: (>60kg): Tabs: 100mg qd. Powder: 100mg qd. Videx EC: 125mg qd. (<60kg): 75mg qd. Powder: 100mg qd. Videx EC: NR

Hemodialysis

dialysis Give 25% of usual dose qd. Supplemental doses are not necessary.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.
Didanosine