*In rare instances, doses of up to 12 grams of ANCEF per day have been used.
[CRCL >55 ml/min]: no change.
[35-54 ml/min]: Maximum interval: q8h. 500mg – 1.5g q8h.
[11-34 ml/min]: 500mg – 1.5g x 1, then 0.5 - 1 gram q12h.
[<10 ml/min]: 500 mg - 1 gram q18-24h.
Dosage Adjustment for Patients With Reduced Renal Function ANCEF may be used in patients with reduced renal function with the following dosage adjustments: Patients with a creatinine clearance of 55 mL/min. or greater or a serum creatinine of 1.5 mg % or less can be given full doses. Patients with creatinine clearance rates of 35 to 54 mL/min. or serum creatinine of 1.6 to 3.0 mg % can also be given full doses but dosage should be restricted to at least 8 hour intervals. Patients with creatinine clearance rates of 11 to 34 mL/min. or serum creatinine of 3.1 to 4.5 mg % should be given 1/2 the usual dose every 12 hours. Patients with creatinine clearance rates of 10 mL/min. or less or serum creatinine of 4.6 mg % or greater should be given 1/2 the usual dose every 18 to 24 hours. All reduced dosage recommendations apply after an initial loading dose appropriate to the severity of the infection.
500 mg – 1 gram IV q24h. (Give dose post-dialysis on dialysis days.)
PD: 500 mg q12h.
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