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Usual Dosing
Adults and Pediatric Patients > 3 Months
* Dosing for infections caused by less susceptible organisms should follow the recommendations for severe infections. † The children’s dosage is intended for individuals whose weight is less than 40 kg. Children weighing 40 kg or more should be dosed according to the adult recommendations.
Infection
Severity*
Usual Adult Dose
Usual Dose for Children >3 Months†
Ear/Nose/ Throat
Mild/ Moderate
500 mg every 12 hours or 250 mg every 8 hours
25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours
Severe
875 mg every 12 hours or 500 mg every 8 hours
45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Lower Respiratory Tract
Mild/ Moderate or Severe
875 mg every 12 hours or 500 mg every 8 hours
45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Skin/Skin Structure
Mild/ Moderate
500 mg every 12 hours or 250 mg every 8 hours
25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours
Severe
875 mg every 12 hours or 500 mg every 8 hours
45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Genitourinary Tract
Mild/ Moderate
500 mg every 12 hours or 250 mg every 8 hours
25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours
Severe
875 mg every 12 hours or 500 mg every 8 hours
45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours
Gonorrhea Acute, uncomplicated ano-genital and urethral infections in males and females
3 grams as single oral dose
Prepubertal children: 50 mg/kg Amoxicillin, combined with 25 mg/kg probenecid as a single dose. NOTE: SINCE PROBENECID IS CONTRAINDICATED IN CHILDREN UNDER 2 YEARS, DO NOT USE THIS REGIMEN IN THESE CASES.
All patients with gonorrhea should be evaluated for syphilis.
Larger doses may be required for stubborn or severe infections.
Renal Dosing
PO: [CRCL >30 ]: No change. [10-29 ml/min]: q8-12h. Do not use 875 mg tablet. [<10 ml/min]: q24h. Do not use 875mg tablet.
Hemodialysis
250 to 500mg q24h plus additional dose after dialysis.
Reference(s)
National Institutes of Health, U.S. National Library of Medicine, DailyMed Database. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates. A local search option of this data can be found here.
