kiss and run fusion

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kiss and run fusion2016-12-30T21:46:09+00:00

kiss and run fusion 

kiss and run fusion image from New Medical Terms

kiss and run fusion

CELL BIOLOGY  

A fanciful term for a type of exocytosis in which a synaptic vesicle docks and temporarily fuses (“kisses) at a porosome in the presynaptic membrane, releasing its content-e.g., neurotransmitters at the synapse, then uncouples. 
Kiss and run advantages over full fusion (in which the vesicle completely collapses):

(1) The vesicle can be reused, and 

(2) The amount of content released can be controlled, depending on the length of the “kiss”.

Examples of sites of kiss and run exocytosis  Pancreatic beta cells and other endocrine and neuroendocrine cells, hippocampus, inner membrane of mitochondria 

Regulation  

• Calcium-dependent actin coating  of vesicles

• Myosin II regulates fusion pore dynamics

• Possibly, SNARE proteins 

References http://en.wikipedia.org/wiki/Kiss-and-run_fusion
Nature Reviews Molecular Cell Biology 2, 738-748 (October 2001) doi:10.1038/35096009

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