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(1) The gene on chromosome 2q33-q34 that encodes caspase 10—apoptosis-related cysteine peptidase (OMIM: 601762, UniProtKB: Q92851), a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development. Caspase 10 is an initiator type caspase which is activated by, and interacts with upstream adaptor molecules through CARD and DED protein-protein interaction domains. It cleaves and activates caspase-3, -4, -6, -7, -8, and -9, is recruited to Fas- and TNFR-1 receptors in a FADD dependent manner, and may participate in the granzyme B apoptotic pathways. It is expressed in most tissues.
Molecular pathology Defects in CASP10 have been linked to gastric cancer, non-Hodgkin lymphoma and cause autoimmune lymphoproliferative syndrome 2A (OMIM:603909).
Synonyms ICE-like apoptotic protease 4, MCH4, ALPS2, apoptotic protease Mch-4, FADD-like ICE2, interleukin-1B-converting enzyme 2, FLICE2, EC 18.104.22.168, FAS-associated death domain protein interleukin-1B-converting enzyme 2
(2) CASP10 is also a less preferred gene symbol for what is now–per HUGO–designated as PPIG