Definition The gene on chromosome 1q44 that encodes protein kinase B–PKB (OMIM:611223, UniProt:Q9Y243), an AKT serine-threonine protein kinase*, which is stimulated by platelet-derived growth factor–PDGF, insulin, and insulin-like growth factor 1. AKT3 plays a key role in brain development. It is a key modulator of several tumours–e.g., melanoma, glioma and ovarian cancer.
*AKT kinases regulate cell signalling in response to insulin and growth factors, and are involved in a wide array of biological processes including cell proliferation, differentiation, apoptosis, and tumorigenesis, as well as glycogen synthesis and glucose uptake.
Synonyms V-Akt murine thymoma viral oncogene homolog 3, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma serine/threonine-protein kinase, EC 22.214.171.124, V-Akt murine thymoma viral oncogene homolog 3 (protein kinase B—gamma), gamma, protein kinase Akt-3, MPPH