H7N9 image from New Medical Terms

ultrastructure of H7N9 virus


A serotype of influenza virus A* which the World Health Organization regards as “unusually dangerous”, as it has features of a mammalian virus, and thus has a greater risk of disseminating in humans. Because there are no tests to detect it in poultry, flock destruction is inappropriate.

*Avian influenza virus, bird flu virus Unlike the H5N1 viral form, H7N9 does not cause visible disease in poultry, which makes surveillance, prevention and control of the virus in poultry difficult. While is seems likely that H7N9 originated from an avian virus, its exact parentage and mode of transmission are unclear.

Clinical findings Fever, cough, pneumonia, acute respiratory distress syndrome

Lab Lymphocytopaenia, thrombocytopaenia

Imaging Bilateral ground-glass opacities and consolidation

Management Influenza antivirals (neuraminidase inhibitors) may be effective in managing clinical disease.

Prognosis There is no vaccine; H7N9infection has a ± 25% mortality; up to 60% of those infected have had prolonged disease; 20% of cases resolve completely.

References N Engl J Med 2013; 368:2277-2285 June 13, 2013
DOI: 10.1056/NEJMoa1305584

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