Clostridium difficile toxin B

Home » Modern Medicine » Microbiology » Clostridium difficile toxin B
Clostridium difficile toxin B2016-12-04T00:54:44+00:00

Clostridium difficile toxin B 

Clostridium difficile toxin B image from Ned Medical Terms

Clostridium difficile toxin B

GASTROENTEROLOGY, MICROBIOLOGY

A 270 kD cytotoxin produced by Clostridium difficile that is 1000-fold more cytotoxic than C difficile toxin A. It has four–catalytic, cysteine protease, translocation, and receptor binding–domains, of which the catalytic domain is the most damaging.

Mechanism Catalytic activation of glucosyltransferase deactivates small GTPases–e.g. Rho, Rac and Cdc42–leading to defective signal transduction, and dysfunction of actin cytoskeleton, cell-cell junction, and apoptosis. 

Reference http://en.wikipedia.org/wiki/Clostridium_difficile_toxin_B

Leave A Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.