carbapenem-resistant Enterobacteriaceae

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carbapenem-resistant Enterobacteriaceae2016-12-25T21:36:41+00:00

carbapenem-resistant Enterobacteriaceae 


Any of the enterobacteriaceae–e.g., Klebsiella pneumoniae, Escherichia coliwhich are resistant to carbapenem*, one of the last broad-spectrum antibiotic to which antibiotic resistant bacteria had previously been susceptible. CRE kill up to half of the patients it infects, especially those with ventilators or indwelling catheters. 

*Via a plasmid transferrable beta-lactamase carried by an increasing number of strains of Klebsiella pneumoniae as well as other Enterobacteriaceae. Hydrolysis of the beta-lactam ring  renders many of the antibiotics–in particular extended spectrum cephalosporins and carbapenems: imipenem, meropenem, and ertapenem–ineffective

Synonyms CRE superbug, nightmare bacteria, carbapenemase-carrying Klebsiella pneumoniae 

References JAMA 2013; 309:1593-1594


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