immunoproteasome

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immunoproteasome2016-12-25T07:45:56+00:00

immunoproteasome 

IMMUNOLOGY

An inducible type of proteasome*, which improves MHC-1 antigen presentation, regulates proinflammatory cytokine production, and T cell differentiation and proliferation. Immunoproteasomes also have other biological functions, including reducing oxidative stress by the efficiently turning over oxidatively-damaged proteins, preventing the formation of harmful protein aggregates; controlling muscle mass; and regulating tumor cell growth.

*Two main functions of proteasomes: (1) Regulate signal transduction; (2) Process antigens for presentation on class I MHC.

Immunoproteasomes are of interest as potential therapeutic targets for cancer and autoimmune disease. 

Reference Front Biosci. 2012 Jan 1;17:1904-16.

 

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