An inducible type of proteasome*, which improves MHC-1 antigen presentation, regulates proinflammatory cytokine production, and T cell differentiation and proliferation. Immunoproteasomes also have other biological functions, including reducing oxidative stress by the efficiently turning over oxidatively-damaged proteins, preventing the formation of harmful protein aggregates; controlling muscle mass; and regulating tumor cell growth.
*Two main functions of proteasomes: (1) Regulate signal transduction; (2) Process antigens for presentation on class I MHC.
Immunoproteasomes are of interest as potential therapeutic targets for cancer and autoimmune disease.
Reference Front Biosci. 2012 Jan 1;17:1904-16.