endogenous pyrogen

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endogenous pyrogen2016-12-25T03:14:06+00:00

endogenous pyrogen

IMMUNOLOGY

Definition Any cytokine–e.g., IL-6, IL-1α, IL-1β, TNF-α, TNF-β, IFN-α, and possibly also IFN-gamma, and macrophage inflammatory protein-1, that induces a febrile reaction—without requiring the formation of another cytokine—typically in a background of an acute phase response

Synonym Granulocytic pyrogen, leukocytic pyrogen

References J Infect Dis. (1999) 179 (Supplement 2): S294-S304.
doi: 10.1086/513856
Perspect Biol & Med 1993; 36:611  

 

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