cytokine stormJoe Segen2016-12-25T03:07:14+00:00
Definition A potentially fatal hyper-release of inflammatory mediators in response to stimulation of T cells and macrophages by pathogens and immune insults
Clinical findings High fever, swelling and redness, extreme fatigue and nausea, in some cases the immune reaction may be fatal; if it occurs in the lungs, fluids and macrophages may accumulate, block airways and cause death
Triggers GVHD–graft versus host disease, ARDS–adult respiratory distress syndrome, sepsis, avian influenza, leptospirosis, SIRS–systemic inflammatory response syndrome.
Whilst there are over 150 known cytokines, the most common culprits of the cytokine storm are pro-inflammatory cytokines–TNF-alpha, IL1, IL-6; anti-inflammatory cytokines–IL-10 and IL-1 receptor antagonist; oxygen free radicals and coagulation factors