CAR therapyJoe Segen2016-12-25T02:55:16+00:00
Definition CAR therapy (CT) is an experimental therapeutic modality (chimeric antigen receptor therapy) which is based on fused (chimeric) receptor proteins.
In CT, single-chain variable fragments (scFv) from monoclonal antibodies recognising tumour-associated antigens are fused to intracellular signalling domains such as the CD3 ζ-chain cytoplasmic tail. Transduction of peripheral T cells with these targeting moieties confers specific cytotoxic immunoreactivity against cells expressing the target epitope. Thusfar, CT has been most effective in shrinking leukaemia, but is not yet a mainstream approach.
Synonym Chimeric antigen receptor therapy
Reference Molecular Therapy (2011) 19 3, 432–438.