CAR therapy

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CAR therapy2016-12-25T02:55:16+00:00

CAR therapy

IMMUNOLOGY

Definition CAR therapy (CT) is an experimental therapeutic modality (chimeric antigen receptor therapy) which is based on fused (chimeric) receptor proteins.

In CT, single-chain variable fragments (scFv) from monoclonal antibodies recognising tumour-associated antigens are fused to intracellular signalling domains such as the CD3 ζ-chain cytoplasmic tail. Transduction of peripheral T cells with these targeting moieties confers specific cytotoxic immunoreactivity against cells expressing the target epitope. Thusfar, CT has been most effective in shrinking leukaemia, but is not yet a mainstream approach. 

Synonym Chimeric antigen receptor therapy

Reference Molecular Therapy (2011) 19 3, 432–438.
doi:10.1038/mt.2011.1 

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