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cancer immunotherapyJoe Segen2016-12-25T02:54:59+00:00
Definition Cancer immunotherapy (CIT) refers to the harnessing of the immune system’s inherent specificity to destroy cancer cells, a therapeutic strategy which is regarded as the fourth* weapon against cancer. Current CITs include antibodies against T cell receptors and genetically engineered T cells that target tumour cells.
*The first three weapons, surgery, radiation therapy and chemotherapy, carry risks and may destroy healthy tissue in addition to the malignant cells.
• Monoclonal antibodies, linked either to
– Immunotoxins, or
• Cancer therapy with T cells, either as
– Allografts of T cells or
– Autografts of T cells–tumour-infiltrating lymphocyte
• Cancer vaccines
References Science 2013; 342:14