Definition A clinical trial that compared a composite end point (death, acute MI, and refractory ischaemia at 48 hours) in patients with unstable angina–who were already receiving aspirin, and managed with either heparin–H or tirofiban–T–a nonpeptide inhibitor of platelet glycoprotein IIb/IIIa receptor
Conclusion Tirofibran reduced mortality, but not acute MIs or refractory ischaemia.
Logistics Double-blind; 3232 patients were enrolled within 24 hours of the “qualifying” episode of pain–chest pain at rest or accelerating chest, and randomly assigned to receive either H or T
Abbreviation for: Platelet Receptor Inhibition in Ischaemic Syndrome Management
Reference NEJM 1998; 338:1498-1505oa
Definition A multicentre therapeutic trial of patients with Paget’s disease
Conclusion No difference in fractures, orthopaedic surgery, quality of life or hearing thresholds between biphosphonate and symptomatic treatment.
Logistics Multicentre, UK, 1,324 patients randomised to biphosphonate or symptomatic treatment.
Abbreviation for The Paget’s Disease: Randomised Trial of Intensive Versus Symptomatic Management
Reference Metabolism J Bone Miner Res 2010; 25:20-31.[/fusion_builder_column][/fusion_builder_row][/fusion_builder_container]