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Definition A clinical trial that compared a composite end point (death, acute MI, and refractory ischaemia at 48 hours) in patients with unstable angina–who were already receiving aspirin, and managed with either heparin–H or tirofiban–T–a nonpeptide inhibitor of platelet glycoprotein IIb/IIIa receptor

Conclusion Tirofibran reduced mortality, but not acute MIsor refractory ischaemia.

Logistics Double-blind; 3232 patients were enrolled within 24 hours of the “qualifying” episode of pain–chest pain at rest or accelerating chest, and randomly assigned to receive either H or T

Abbreviation for: Platelet Receptor Inhibition in Ischaemic Syndrome Management 

Reference NEJM 1998; 338:1498-1505oa


Definition A multicentre therapeutic trial of patients with Paget’s disease

Conclusion No difference in fractures, orthopaedic surgery, quality of life or hearing thresholds between biphosphonate and symptomatic treatment.

Logistics Multicentre, UK, 1,324 patients randomised to biphosphonate or symptomatic treatment. 

Abbreviation for The Paget’s Disease: Randomised Trial of Intensive Versus Symptomatic Management 

Reference Metabolism J Bone Miner Res 2010; 25:20-31.


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