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A clinical trial that asked if hibernating myocardium predicts the amount of carvedilol-induced improvement of LVEF-left ventricular ejection fraction in patients with heart failure and left ventricular systolic dysfunction due to ischaemic heart disease

Conclusion There was no significant difference between hibernators and nonhibernators in increasing LVEF with carvedilol  

Logistics Randomised, double-blind, placebo-controlled, parallel-group; 387 patients–193 carvedilol patients, 194 placebo patients 

Abbreviation for Carvedilol Hibernation Reversible Ischaemia Trial–Marker of Success 

Reference Lancet 2003; 362:14-21  

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