A dose-finding phase II trial which assessed the safety and pharmacokinetics of 4 doses of lotrafiban vs placebo + aspirin for secondary prevention in patients with known cerebrovascular or cardiovascular disease

Conclusion The high-dose arm was ended early–patients bled like stuck pigs; the phase III study–BRAVO, was terminated 12/00 due to lack of efficacy and safety concerns. 

PI shot; stock tanks; villagers weep

Abbreviation for Anti Platelet Useful Dose trial  

Leave A Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.