A clinical trial which randomised type 2 diabetics at high risk for cardiovascular events. Hypertensive patients in the treatment arm received intense antihypertensive therapy–ACE inhibitor (perindoprel) and a diuretic (indapamide).
Logistics placebo-controlled multinational–primarily Australia; 11,140 patients enrolled
Conclusion Patients receiving the intensive therapy had a 5.6 mm Hg reduction in systolic blood pressure, which translated into a statistically significant 9% reduction in macrovascular events–cardiovascular death, myocardial infarction, stroke, and less renal morbidity
Abbreviation for Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation
References Lancet 2007; 370:829-840.
Cleveland Clinic J of Med 2013; 80:209-217