A multicentre trial that randomised 11,000 high-risk hypertensives to receive an ACE inhibitor (benazepril) plus a calcium channel blocker (amlodipine) or an ACE inhibitor plus a thiazide diuretic (hydrochlorothiazide).
Conclusion The trial was ended early because of the higher mortality and morbidity in the ACE inhibitor/thiazide diuretic arm.
Abbreviation for Avoiding Cardiovascular Events Through Combination Therapy in Patients Living with Systolic Hypertension
References Cleveland Clinic J of Medicine 2013; 80:209-217
N Engl J Med 2008; 359:2417-2426