intention to treat

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intention to treat2016-12-13T03:47:38+00:00

intention to treat 

EVIDENCE-BASED MEDICINE

adjective A term defined in the context of clinical trials, referring to the principle or stance that the effect of a treatment regimen is best assessed by evaluating the basis of the intention to treat a subject–i.e., the planned treatment regimen, rather than the actual treatment given.

Thus, subjects allocated to a treatment group should be followed, assessed, and analysed as members of the treatment group irrespective of their compliance with the planned course of treatment. Intention to treat protocols are meant to prevent bias caused by loss of trial participants which may reflect non-adherence to the protocol and disrupt baseline equivalence established by random assignment. 

Synonym Intent to treat 

Reference http://www.appliedclinicaltrialsonline.com/appliedclinicaltrials/article/articleDetail.jsp?id=700052&sk=&date=1&pageID=19

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