Definition A proposed autoimmune condition allegedly linked to the leaking of silicone from breast implants and other prosthetic devices into surrounding breast and/or systemic penetration thereof
Alleged clinical findings Fatigue, myalgia, arthralgia, synovitis, serositis, sicca syndrome–dry eyes and mouth, dermatitis, alopecia, lymphadenopathy, gastrointestinal symptoms, fever, night sweats, and cognitive dysfunction
Diagnosis Clinical features, history, microscopy, inductively coupled plasma emission spectroscopy.
Note: Multiple longitudinal peer-reviewed studies have been performed to assess this so-called condition. All have concluded that there is no causal link between silicone implants and connective tissue disease. A Canadian study found a 40% reduction in breast cancer in patients with implants (presumably due to increased surveillance)
Micro Inflammation, calcification, giant cells, foamy histiocytes, vacuoles containing colourless refractory material–silicone, fibrosis
Synonyms Atypical silicone disease, silicone allergy, silicone poisoning, silicone reactive disorder, siliconosis