obesogen

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obesogen

BARIATRIC MEDICINE

Definition An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, and disrupts energy balance or modifies the regulation of appetite and satiety, resulting in fat accumulation and obesity.

Obesogen mechanisms of action Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones

Obesogens 

Pharmaceutical obesogens

• Metabolic sensor  Act on PPAR-gamma receptor–e.g., thiazolidinediones, rosiglitazone

• Sex steroid dysregulation  DES–caused obesity in adults

• Central  Act on neurotransmitter receptors–e.g., SSRIs, antidepressants

Environmental obesogens

• Organotin

• Xernobiotics

References en.wikipedia.org/wiki/Obesogen
Mol. Endocrinol. 24 (3): 526–39 (2010)
doi:10.1210/me.2009-0261

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