Manchester sailor

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Manchester sailor2016-12-25T20:57:54+00:00

Manchester sailor

AIDS, EPIDEMIOLOGY

A man who died of an unknown, presumably immune, disease in 1959 who, for a time, was regarded as the index case of the AIDS epidemic

Early reports in the AIDS literature (Lancet 1990; 336:51) had incorrectly concluded that the Manchester man was the first known case of AIDS–i.e., the so-called Patient Zero. He was not in fact a sailor, but rather an apprentice printer who served at sea. His primacy in the AIDS epidemic was questioned by Zhu and Ho, who constructed a phylogenic tree using the neighbour-joining method and believed that the HIV-1 identified in the PCR analysis reported in 1990 was more recent in evolution; the results were subsequently acknowledged to be “anomalous”.

Synonym Patient Zero 

References Lancet 1960; ii:951
www.aegis.com/news/misc/1995/IN950301.html

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