postorgasmic illness syndrome

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postorgasmic illness syndrome2016-12-10T18:35:13+00:00

postorgasmic illness syndrome


A recently described controversial condition characterised by debilitating symptoms lasting several hours to days after an orgasm, and said to affect up to 1% of the general population.

This entity has been legitimised by formal recognition by the NIH’s Office of Rare Diseases Research, and National Organization for Rare Disorders–NORD

Clinical findings

Mental Cognitive dysfunction, discomfort, irritability, anxiety, increase susceptibility to cold or other stressors, depression, difficulty in communicating, remembering words, reading and retaining information, concentrating, and socialising

Physical Fatigue, headache, flu-like and allergy-like symptoms–e.g., sneezing, itchy eyes, nasal irritation, and muscle pain, sensation of intense warmth

Imaging Pituitary changes–e.g., microadenoma

Lab Decreased progesterone, testosterone; increased cortisol

Management Uncertain; SSRIs, hormone therapy, hyposensitisation for semen allergies, abstention from sex


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