Daniel Webster forehead

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Daniel Webster forehead2016-12-09T16:09:34+00:00
Daniel Webster image from New Medical Terms

Daniel Webster and his forehead

Daniel Webster forehead


Definition A descriptive term for the high, squarish forehead typical of the Smith-Lemli-Opitz syndrome (OMIM:270400), which has been fancifully likened to that of Daniel Webster (1782 – 1852).

Molecular pathology Smith-Lemli-Opitz syndrome is caused by a defect of DHCR7, which encodes 7-dehydrocholesterol reductase, a ubiquitously expressed membrane bound enzyme that converts 7-dehydrocholesterol to cholesterol.

Comment Webster was an American statesman prior to the US Civil War. He is not the dictionary Webster, an honour which goes to Noah Webster, educator and Daniel’s contemporary.

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