ugly

ugly2016-12-08T02:45:22+00:00

ugly  

adjective Referring to something that isn’t attractive or pretty which, in medicine, is “code” for an aggressive disease or lesion.

INFECTIOUS DISEASE

An ugly infection is one that responds poorly to aggressive antibiotic therapy, and is more common in immunocompromised patients or those with terminal cancer. 

ONCOLOGY

An ugly malignancy is characterised by brisk and often metastatic growth, fulminant clinical disease, rapid deterioration, multiorgan failure, infection, and poor response to therapy. 

PATHOLOGY

Ugly usually refers to a malignant lesion with bizarre, poorly differentiated cells characterised by marked nuclear atypia, pleomorphism, florid mitotic activity, and necrosis–e.g., giant cell tumour of the lung. 

The lineage of these cells is often unclear, and may require the use of ancillary studies–e.g., IHC stains for the presence of intermediate filaments or molecular studies; ugly tumours may be so anaplastic that their origin doesn’t yield to special studies.  

VOX POPULI Not attractive

Leave A Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.