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WARFARIN DOSE PREDICTION EQUATION

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Patient Parameters
Age:      Specify race:  
Height
:     Weight:
Target INR
Target INR
Concomitant conditions
Patient receiving amiodarone:  
Smoker     
DVT or PE present?
:

Equations  Used:

BSA

1]  (Weight) kg0.425 x   (Height) cm0.725 x  0.007184 = BSA in M2
    
Reference
: DuBois D, DuBois DF. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 1916;17:863-71.




Warfarin Dose Prediction

2]   exp [0.613 + (0.425 x BSA) - (0.0075 x age)  + (0.156 x African-American race)
            + (0.216  x target INR) - (0.257 x amiodarone) + (0.108  x smokes) 
                + 0.0784  x  DVT/PE ]

Reference:  Gage BF, Eby C, Johnson JA, Deych E, Rieder MJ, et al. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther. 2008 Sep;84(3):326-31. Epub 2008 Feb 27.


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Warfarin Dose Estimation Calculator