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NON-STEADY STATE - Dosing By Levels

Patient-Specific Data

Patient:     Location:
dose by levels  
 

Current Levels Data

1st level - Concentration:  mcg/ml    
1st level (number hours post dose): hr
2nd level - Concentration: mcg/ml   
2nd level (number hours post dose):  hr
3rd level - Concentration: mcg/ml  
3rd level (number hours post dose): hr

Current Drug Regimen

Current dose being given mg     Current dosing interval: (hours)
Current infusion time (hours):
Desired peak: mcg/ml     Desired trough: mcg/ml
Sample problems
Scenario 1:  (Levels off the first dose)
Regimen:  Tobramycin 140mg (infused over 30 minutes) IVPB q8h. Two post levels are drawn after the first dose.   The first level (level 2 in the figure below) was drawn 2 hours after the 'start' of the infusion, while the second level (level 3) was drawn 6 hours after the 'start' of the infusion.  You will notice a zero was entered for the 1st level concentration and the number of hours post dose. Next, notice that the the number of hours post dose for the 2nd and 3rd level included the infusion period of 30 minutes. It is IMPORTANT not to subtract the infusion time from the number of hours post dose. The program will take care of this for you.
Non-Steady State kinetics now available
Scenario 2:  (Levels off the second dose)
Regimen:  Tobramycin 140mg (infused over 30 minutes) IVPB q8h. A pre-level was drawn 7 hours after the 'start' of the infusion of the first dose.  Two post levels are drawn after the second dose.   The first level (level 2 in the figure below) was drawn 2 hours after the 'start' of the infusion, while the second level (level 3) was drawn 6 hours after the 'start' of the infusion.  Notice that the the number of hours post dose for the 1st, 2nd and 3rd level included the infusion period of 30 minutes.
It is IMPORTANT not to subtract the infusion time from the number of hours post dose. The program will take care of this for you.

Program HINT: If the pre-level (level 1) was drawn just prior to the infusion of the next dose, the number of hours post dose would be 8 in this example.
Non-Steady State kinetics now available

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Non-Steady State kinetics -Dosing by levels