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Calculation of the Total Iron Deficit – Alternative equation
Calculation of the Total Iron Deficit – Alternative equation [Explained]
Feel free to use our complete database with charts, tables and examples.
Calculation of Parenteral Iron Dose (Iron Deficit)
Equations:
Hemoglobin iron deficit (mg)
=
weight (kg) x (14  Hgb) x (2.145)
^{1}
Note
: Hbg (current hemoglobin level) units: (g/dL)
Alternatively
:
Volume of product required (mL)
= [weight (kg) x (14  Hgb) x (2.145)] / C
Where C= concentration of elemental iron (mg/ml) in the product being used:
Iron dextran: 50 mg/mL. Iron sucrose: 20 mg/mL. Ferric gluconate: 12.5 mg/mL
Note (alternative equations)
:
[1 ] The
Iron dextran
package insert lists the following equation:
Dose (mL) = 0.0442 (Desired Hb  Observed Hb) x LBW + (0.26 x LBW)
Iron dextran calculator can be found
here
.
[2 ] The current package insert for
CosmoFer®
lists the following equation:
Total iron deficit = Body weight [kg] x (Target Hb – Actual Hb) [g/l] x 2.4 + Iron stores [mg]
500 mg iron for iron stores is recommended if the body weight is above 35 kg.
A calculator using this equation can be found
here
.
Patient Weight
:
Kilograms
Pounds
Current Hemoglobin level
:
4
5
6
7
8
9
10
11
12
13
g/dL
Target (desired) Hemoglobin level
:
13
14
15
g/dL
Background:
Iron deficit  equation derivation
^{1}
:
Assumptions
:
Blood volume = 65 mL/kg
Hgb conc target =14.0 g/dL
Deficits in body stores are ignored.
Intermediate calculations
:
Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL)
Hgb deficit (g/dL) = 14.0  patient hgb conc.
Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL)
Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb)
[Note: 3.3 x 0.65 = 2.145]
Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL)
Final calculations
:

Hgb iron deficit (mg) = weight (kg) x (14  Hgb) x (2.145)

Volume of product required (mL) = [weight (kg)x (14  Hgb) x (2.145)] / C
Where C= concentration of elemental iron (mg/ml) in the product being used:
Iron dextran: 50 mg/mL. Iron sucrose: 20 mg/mL. Ferric gluconate: 12.5 mg/mL
References:
Iron deficit equation
(
source
):
[1 ] Schrier SL, Mentzer WC, Landaw SA. Treatment of anemia due to iron deficiency. UpToDate®. 2010;18(3). https://www.uptodate.com/ (Requires subscription). Accessed: 4/12/2011.
Alternative equation
:
Total iron deficit = Body weight [kg] x (Target Hb – Actual Hb) [g/l] x 2.4 + Iron stores [mg]
500 mg iron for iron stores is recommended if the body weight is above 35 kg.
[2 ] CosmoFer® package insert and product website: https://www.cosmofer.com/product/dosecalculation/dosecalculator.aspx
Iron Deficiency  Anemia
Calculators / Tools
This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach.
Iron deficiency anemia calculator (diagnosis)
Iron deficiency anemia vs. Anemia of chronic disease (ACD)
Iron Deficit  MultiCalc
Calculation of the Total Iron Deficit – equation appears in Cosmofer PI
Calculation of the Total Iron Deficit – Alternative equation
Iron Dextran Dosing Calculator (iron deficit)
Tables / Articles / Dilutions
Iron Dextran Dilution
Iron Sucrose Dilution
Oral and parenteral products  see background option for oral products.