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## Pharmacokinetic Dosing Calculator (2019)

This latest version is based on a comprehensive review of the most recent pharmacokinetic textbooks. Some of the sources used are listed here.

Link to the standalone Vancomycin AUC related dosing Calculator >>

#### Patient-Specific Data

Patient: Location:
Age: Sex: Serum Creatinine:
Height
: Weight:

Clearance method
:

#### Drug Selection, Levels, and Drug-specific PK Parameters:

Select Drug: Desired Peak: mcg/ml

Desired Trough: mcg/ml
Volume of distribution:
L/kg
Usual range: aminoglycosides: 0.25 - 0.35.
Vanco: 0.65 - 0.9
Infusion time (ti):

#### Select elimination rate constant (Ke) calculation method:

Background information
(VANCOMYCIN)
:
Ke = 0.00083 x CRCL + 0.0044 Usual Vd reported: 0.9 L/kg. (0.7 - 0.9 L/kg) Ref: 3,4,5
Clearance method: CL (L/hr) = CrCl (ml/min) x 0.06. Ke = Vanco CL/Vd. Usual Vd: 0.7L/kg. Ref: 6
Ke (hr-1) = [(0.695[(CrCl mL/min)/TBW kg] + 0.05) x 0.06] / Vd factor ] Usual Vd: 0.7L/kg. Ref: 2

New option based on input from clinicians - general assumption, adjusted body weight may be used in the morbidly obese patients receiving vancomycin: Historically actual or total is used in all cases.
Use Adjusted body weight or Use Actual (total) weight for vanco dosing.

(Aminoglycosides)
:
Clearance method: CL (L/hr) = CrCl (ml/min) x 0.06. Ke = CL/Vd. Ref: 5,6
Ke = 0.00293(CrCl) + 0.014 Ref: 1,4
Ke (hr-1) = (0.0024 x CrCl) + 0.01 Ref: 5

(optional)
(optional)

# Cockcroft and Gault equation utilizing the ibw (Ideal body weight) to calculate an estimated creatinine clearance

Cockcroft and Gault equation:
CrCl = [(140 - age) x IBW] / (Scr x 72) (x 0.85 for females)
Note: if the ABW (actual body weight) is less than the IBW use the
actual body weight for calculating the CRCL.

Estimate Ideal body weight in (kg)
Males: IBW = 50 kg + 2.3 kg for each inch over 5 feet.
Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 feet.

## Salazar-Corcoran Equation

Estimating Creatinine Clearance (ml/min) - Units: Weight: kg Height: meters.
For Men:
[137 - age] x [(0.285 x weight(kg)) + (12.1 x height(m)2)] / (51 x SCr)

For Women:
[146 - age] x [(0.287 x weight(kg)) + (9.74 x height(m)2)] / (60 x SCr)

Salazar DE, Corcoran GB: Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass. Am J Med 84: 1053–1060, 1988.

## References

1. Bauer LA. The Aminoglycoside Antibiotics. In Bauer LA, ed. Applied Clinical Pharmacokinetics. 2nd ed. New York, NY: McGraw Hill Medical; 2008:97-206.

2. Bauer LA. Vancomycin. In Bauer LA, ed. Applied Clinical Pharmacokinetics. 2nd ed. New York, NY: McGraw Hill Medical; 2008:207-298.

3. Burton ME, Shaw LM, Schentag JJ, Evans WE. Applied Pharmacokinetics & Pharmacodynamics: Principles of Therapeutic Drug Monitoring. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2006.

4. DiPiro JT, Spruill WJ, Wade WE, Blouin RA, Pruemer JM. Concepts in Clinical Pharmacokinetics, (5th Edition) 2010. American Society of Health Systems Pharmacist, Bethesda, MD.

5. Murphy JE. Aminoglycosides. In: Murphy JE, ed. Clinical Pharmacokinetics, 4th ed. Bethesda, MD: American Society of Health-System Pharmacists, 2008:27-60.

6. Winter ME. Basic clinical pharmacokinetics. 5th ed. Baltimore: Lippincott Williams and Wilkins; 2010.
7. Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy 2012; 32: 604-612 [PMID: 22576791 DOI: 10.1002/j.1875-9114.2012.01098.x]
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