Definition A 244-kD parasite antigen expressed in schizont-infected RBCs. Antibodies targeting PfSEA-1 reduce parasite replication by arresting schizont rupture and egress from RBCs.

Mice vaccinated with recombinant Plasmodium berghei PbSEA-1 had a significant reduction in parasitaemia and delayed mortality after an otherwise lethal challenge with Plasmodium berghei strain ANKA. Therapeutic targeting by blocking schizont egress from RBCs may synergise with other potential P falciparum vaccines targeting hepatocyte and RBC invasion. 

Abbreviation for Plasmodium falciparum schizont egress antigen-1

Reference Science 2014; 344:871-877

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