Definition A 244-kD parasite antigen expressed in schizont-infected RBCs. Antibodies targeting PfSEA-1 reduce parasite replication by arresting schizont rupture and egress from RBCs.
Mice vaccinated with recombinant Plasmodium berghei PbSEA-1 had a significant reduction in parasitaemia and delayed mortality after an otherwise lethal challenge with Plasmodium berghei strain ANKA. Therapeutic targeting by blocking schizont egress from RBCs may synergise with other potential P falciparum vaccines targeting hepatocyte and RBC invasion.
Abbreviation for Plasmodium falciparum schizont egress antigen-1
Reference Science 2014; 344:871-877