A chemical of the tryptamine family that is structurally similar to psilocin, a chemical present in many mushrooms, which acts as a hallucinogen.

It is widely present in plants and in trace amounts in mammals, including humans, where it may act as a trace neurotransmitter/ neuromodulator.

Chemical names Dimethyltryptamine, N,N-Dimethyltryptamine, N,N-DMT

Street names 45 minute trip, AMT, Businessman’s Trip, diabetesT, Disneyland, Disneyworld, Instant Psychosis, Psychosis, special LSD

Hallucinogenic effects DMT evokes profound time-dilation, visual and auditory hallucinations, and other experiences including erotic imagery and sensations that defy description (and gravity).

Routes Inhalation, injection, snortation, oralation–but it is chemically unstable and destroyed by intestinal enzymes 

Side effects–clinical Mild hypertension, tachycardia, pupillary dilation, and rectal temperature

Side effects–laboratory Increased beta-endorphin, corticotropin, cortisol,  prolactin

Chemistry DMT derives from tryptophan and is produced by the enzyme INMT–indolethylamine N-methyltransferase.

Serotonin receptor binding Much of DMT’s psychedelic effects can be attributed to a functionally selective activation of the 5-HT2A receptor.

DMT binds non-selectively to 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, and 5-HT7, and has agonist activity at 5-HT1A, 5-HT2A and 5-HT2C. DMT also has affinity for dopamine D1, α1-adrenergic, α2-adrenergic, imidazoline-1, sigma-1 (σ1), and TAAR–trace amine-associated receptors. Agonist at the rat trace amine-associated receptor 1–TAAR1.


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