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nude mouseJoe Segen2016-12-25T08:31:45+00:00
Definition A mutant strain of mice which is hair-less, thymus-less and T cell-less due to congenital thymic aplasia.
Genetics Nude mice have a spontaneous deletion of FOXN1, which encodes forkhead box N1, a transcriptional regulator involved in development, especially of the immune system. Humans with defective FOXN1 have T-cell immunodeficiency—congenital alopecia—and nail dystrophy OMIM:601705.
Comment Nude mice must be raised in a germ-free–gnotobiotic environment to survive normal environmental flora. They are especially useful for studying graft-versus-host disease.
Nude mice cannot
• Form antibodies, which requires CD4+ helper T cells
• Generate a cell-mediated immune responses, which requires CD4+ and/or CD8+ T cells
• Mount delayed-type hypersensitivity response, which requires CD4+ T cells
• Kill virus-infected or malignant cells, which requires CD8+ cytotoxic T cells
• Reject grafts, which requires both CD4+ and CD8+ T cells