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Clinical pharmacology

Initial U.S. Approval:  2015

Mechanism of Action:  The mechanism of action of brexpiprazole in the treatment of major depressive disorder or schizophrenia is unknown. However, the efficacy of brexpiprazole may be mediated through a combination of partial agonist activity at serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors.

Indications and usage 

INDICATIONS AND USAGE:
REXULTI is indicated for:
• Adjunctive treatment of major depressive disorder (MDD).

• Treatment of schizophrenia

Dosage and administration 

Drug UPDATES: REXULTI ®- brexpiprazole tablet
[Drug information  /  PDF]    Click link for the latest monograph
Dosing:  Click (+) next to Dosage and Administration section (drug info link)

How supplied

HOW SUPPLIED: Tablets: 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4 mg

Reference

[Drug information  /  PDF]    Click link for the latest monograph

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

REXULTI ®