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Glaucoma - Fixed Combination Medications (Ophthalmology)

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Fixed Combination Medications


  1. As many as 40 to 50% of patients require more than one eye drop to control intraocular pressure.
  2. Combinations are chosen for their synergy. The combinations are more effective than either component alone.
  3.  Combinations of timolol and a prostaglandin analog have not resulted in satisfactory reductions in the IOP.
  4. Fixed combinations are more cost effective and reduce exposure to preservatives compared to two separate drops.

Available Products in the U.S.

  • Cosopt® - Dorzolomide HCI & Timolol Maleate:  
    : The dose is one drop of COSOPT in the affected eye(s) two times daily.
  • Cosopt® PF - Dorzolomide HCI & Timolol Maleate:  
    : The dose is one drop of COSOPT PF in the affected eye(s) two times daily. [PRESERVATIVE-FREE]
  • ROCKLATAN® (netarsudil and latanoprost ophthalmic solution) 0.02%/0.005% -  Dosing: One drop in the affected eye(s) once daily in the evening
  • COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5:  Dosing: One drop in the affected eye(s), twice daily approximately 12 hours apart
  • SIMBRINZA® (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2:   Dosing: Shake well before use. Instill one drop in the affected eye(s) three times daily.



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National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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Fixed Combination Medications Ophthalmology