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AMPICILLIN/SULBACTAM (UNASYN ®)
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|[0 - 1.5 grams/ 50 ml] [30 min]
[Over 1.5 grams/ 100 ml] [30 min]
Stability / Miscellaneous
DOSAGE AND ADMINISTRATION
Ampicillin and Sulbactam for Injection may be administered by deep intramuscular injection. (See Preparation for Intramuscular Injection.)
The recommended adult dosage of Ampicillin and Sulbactam for Injection is 1.5 g to 3 g every six hours. The total dose of sulbactam should not exceed 4 grams per day.
Impaired Renal Function
DIRECTIONS FOR USE
Preparation for Intravenous Use
Initially, the vials may be reconstituted with Sterile Water for Injection to yield solutions containing 375 mg Ampicillin and Sulbactam per mL (250 mg ampicillin/125 mg sulbactam per mL ). An appropriate volume should then be immediately diluted with a suitable parenteral diluent to yield solutions containing 3 to 45 mg Ampicillin and Sulbactam per mL (2 to 30 mg ampicillin/1 to 15 mg sulbactam/per mL).
Preparation for Intramuscular Injection
Vials for intramuscular use may be reconstituted with Sterile Water for Injection USP, 0.5% Lidocaine Hydrochloride Injection USP or 2% Lidocaine Hydrochloride Injection USP. Consult the following table for recommended volumes to be added to obtain solutions containing 375 mg ampicillin and sulbactam per mL (250 mg ampicillin/ 125 mg sulbactam per mL).
Note: Use only freshly prepared solutions and administer within one hour after preparation.
Revised: June 2006