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Sodium Chloride 3%
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|513 meq/ 1000 ml (3%)
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Stability / Miscellaneous
|Sodium (normal range): 136 to 147 meq/l.The goal of treatment is to get the patient out of immediate danger (return sodium level to > 120 meq/l). Usually reserved for severe symptomatic hyponatremia (level usually < 115). The maximum rate of increase (sodium level) is 2 meq/L/hr. The usual rate is 0.5 to 1 meq/L/hr-- these lower rates help avoid serious CNS complications (cerebral edema, pontine myelinolysis,seizures) and/or pulmonary edema.
Always verify the infusion rate and the length of infusion based on patient weight and sodium level.
Calculation of the sodium deficit:
Example: 70kg male. Na+= 110 meq/l Desired target= 125 meq/l.
[0.6 x 70kg x (125-110)= 630 meq of Na+ needed].
Amount needed to increase serum sodium level by 1 meq/l/hr= 0.6 x 70kg x 1.0= 42 meq/hr (safe rate for this patient).
3%--hypertonic saline contains 513 meq/liter.
Therefore: [desired rate per hr] / 513 x 1000 = infusion rate (ml/hr).
Desired rate= 42/513 meq x 1000= 82 ml/hr
Infusion time= [630 meq] / [42 meq/hr] = 15 hrs.
Therefore: Infuse 3% saline at 82 ml/hr for 15 hours.
Always verify the infusion rate and the length of infusion (using the calculations above) versus what is ordered.