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Metoclopramide (Reglan ®)
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|NS , D5W|
Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|[All doses] [50 ml] [30 min]|
Stability / Miscellaneous
| DOSAGE AND ADMINISTRATION
For the Relief of Symptoms Associated with Diabetic Gastroparesis (Diabetic Gastric Stasis): If only the earliest manifestations of diabetic gastric stasis are present, oral administration of metoclopramide may be initiated. However, if severe symptoms are present, therapy should begin with metoclopramide injection (IM or IV). Doses of 10 mg may be administered slowly by the intravenous route over a 1 to 2 minute period.
Administration of Metoclopramide Injection, USP up to 10 days may be required before symptoms subside, at which time oral administration of metoclopramide may be instituted.
For the Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy: For doses in excess of 10 mg, Metoclopramide Injection, USP should be diluted in 50 mL of a parenteral solution.
All dilutions may be stored unprotected from light under normal light conditions up to 24 hours after preparation. Intravenous infusions should be made slowly over a period of not less than 15 minutes, 30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two doses, then every 3 hours for three doses. The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combination. For less emetogenic regimens, 1 mg/kg per dose may be adequate. If extrapyramidal symptoms should occur, inject 50 mg Benadryl® (diphenhydramine hydrochloride) intramuscularly, and EPS usually will subside.
For the Prevention of Postoperative Nausea and Vomiting: Metoclopramide Injection, USP should be given intramuscularly near the end of surgery. The usual adult dose is 10 mg; however, doses of 20 mg may be used.
To Facilitate Small Bowel Intubation: If the tube has not passed the pylorus with conventional maneuvers in 10 minutes, a single dose (undiluted) may be administered slowly by the intravenous route over a 1 to 2 minute period.
The recommended single dose is:
To Aid in Radiological Examinations: In patients where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine, a single dose may be administered slowly by the intravenous route over a 1 to 2 minute period.
For dosage, see intubation, above.
Use in Patients with Renal or Hepatic Impairment:
See package insert OVERDOSAGE section for information regarding dialysis.
Metoclopramide undergoes minimal hepatic metabolism, except for simple conjugation. Its safe use has been described in patients with advanced liver disease whose renal function was normal.
NOTE: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Physically and Chemically Compatible Up to 48 Hours
Physically Compatible Up to 48 Hours
Physically Compatible Up to 24 Hours (Do not use if precipitation occurs)
Conditionally Compatible(Use within one hour after mixing or may be infused directly into the same running I.V. line)
Incompatible (Do Not Mix)
Metoclopramide Injection, USP, 5 mg/mL metoclopramide base (present as the monohydrochloride monohydrate) is supplied in the following:
NDC No. Container Concentration Size Quantity
0409-3413–01 Ampul 5 mg/mL 2 mL 25 per container
Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.]
Protect from light by retaining in package until time of use.
This product is light sensitive. It should be inspected before use and discarded if either color or particulate is observed.
Do not store open single-dose vials or ampuls for later use, as they contain no preservative. Discard unused portion.
Source: [package insert]