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Pentobarbital ( Nembutal ®)
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|Maximum rate: 50 mg/min
[100 mg] [50 ml]
[500 – 2000 mg] [250 ml](Concentrations from 0.5 to 8 mg/ml appear to be stable)
Infusion rate: As directed.
Stability / Miscellaneous
|EXP: 12 to 24 hrs (RT) variable (Review specialized reference for additional info).
Label: Do not refrigerate.Onset: 15-60 min
(Oral): 1-4 hrs (IV): 15 min
May be given deep IM (max 250mg per site) or by slow IV injection. Note: can be given IV undiluted.
Preoperative sedation: IM: 150-200 mg.
Barbiturate coma in head injury patients: IV loading dose of 5-10 mg/kg over 1 to 2 hours. Maintenance: Initial: 1 mg/kg/hr; may increase to 2-3 mg/kg/hr. Monitor for dose-dependent cardiovascular and respiratory depression. Maintain serum concentration at 2-4 mg/dl.
Supplied: 50mg/ml-1ml, 2 ml, 20ml, 50ml. (C-II)
DOSAGE AND ADMINISTRATION
There is no average intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that can be relied on to produce similar effects in different patients. The possibility of overdose and respiratory depression is remote when the drug is injected slowly in fractional doses.
A commonly used initial dose for the 70 kg adult is 100 mg. Proportional reduction in dosage should be made for pediatric or debilitated patients. At least one minute is necessary to determine the full effect of intravenous pentobarbital. If necessary, additional small increments of the drug may be given up to a total of from 200 to 500 mg for normal adults.
Special patient population
Source: [package insert]