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Mesna ( Mesnex ®)
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|[Usual dose] [100 ml] [15-30min]
(Concentration range: 1-20 mg/ml)
Stability / Miscellaneous
|Dosing: usual dose=20% of ifosfamide dose given just before and 4 and 8 hours after ifosfamide (total=60%).
May also be given as a continuous IV infusion concurrently with ifosfamide. Total daily dose= 60% to 160% of ifosfamide dose or 60% to 200% of cyclophosphamide dose. May give 20% W/W 15min prior, and then q3hrs x 3-6 doses.Administration: IVPB in 50 ml or more of D5W or normal saline over 5 minutes or longer. Also by continuous IV infusion.Storage/stability: Vials stored at RT. Diluted solutions (1-20 mg/ml)-24 hrs (REF). 20 mg/ml (D5W)-48hrs RT; 1-mg/ml (D5W)-24 hours RT.Preparation: May be further diluted in D5W, NS, D5/.45NS, or LR to a final concentration of 1-20 mg/ml.
DOSAGE AND ADMINISTRATION
The recommended dosing schedule is outlined below:
Preparation of Intravenous Solutions/Stability
*5% Dextrose Injection, USP
Diluted solutions are chemically and physically stable for 24 hours at 25°C (77°F).
Mesna is not compatible with cisplatin or carboplatin.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Manufactured by: Manufactured for:
Source: [package insert]