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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
|[1 gram] [ 50 ml] [30 min]
[2 grams] [100 ml] [60 min]
[3 grams] [100 ml] [2 hours]
[4 grams] [250 ml] [3 hours]
Stability / Miscellaneous
|1 gram = 8.12 meq.
Maximum rate: 1 gram/ 7 minutes.Normal range:1.5 to 2.5 meq/L or 1.7 to 2.6 mg/dl.Magnesium content:
Mag Oxide: 49.6 meq/gram
Mag Gluconate: 4.5 meq/gram
MOM: @ 13.4 meq/5 ml
DOSAGE AND ADMINISTRATION (Package insert)
Both intravenous and intramuscular administration are appropriate. Intramuscular administration of the undiluted 50% solution results in therapeutic plasma levels in 60 minutes, whereas I.V. doses will provide a therapeutic level almost immediately. The rate of I.V. injection should generally not exceed 150 mg/minute (1.5 mL of a 10% concentration or its equivalent), except in severe eclampsia with seizures (see below).
Solutions for intravenous infusion must be diluted to a concentration of 20% or less prior to administration. The diluents commonly used are 5% Dextrose Injection, USP and 0.9% Sodium Chloride Injection, USP. Deep intramuscular injection of the undiluted (50%) solution is appropriate for adults, but the solution should be diluted to a 20% or less concentration prior to such injection in children.
In Magnesium Deficiency
For controlling seizures associated with epilepsy, glomerulonephritis or hypothyroidism, the usual adult dose is 1 g administered I.M. or I.V.
In paroxysmal atrial tachycardia, magnesium should be used only if simpler measures have failed and there is no evidence of myocardial damage. The usual dose is 3 to 4 g (30 to 40 mL of a 10% solution) administered I.V. over 30 seconds with extreme caution.
For reduction of cerebral edema, 2.5 g (25 mL of a 10% solution) is given I.V.
The potential incompatibility will often be influenced by the changes in the concentration of reactants and the pH of the solutions.
It has been reported that magnesium may reduce the antibiotic activity of streptomycin, tetracycline and tobramycin when given together.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Do not administer unless solution is clear and container is undamaged. Discard unused portion.
Source: [package insert]