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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
| [1 to 5 mg] [250 ml] [Titrate]
Central line required for administration.
Stability / Miscellaneous
| EXP: 1 DAY (RT).
Cardiac arrest: 0.5 to 1 mg bolus (1:10,000) q5min prn. May give 0.3 mg SC or start continuous infusion (range: 1 to 10 mcg/min).
Calculation of drip rate (ml/hr)
Intratracheal: Administer 2-2.5 times the recommended I.V. dose; dilute in 10 mL NS or distilled water. Note: Absorption is greater with distilled water, but causes more adverse effects on PaO2.
Bronchodilator: I.M., SubQ ( 1:1000 ): 0.1-0.5 mg every 10-15 minutes to 4 hours
Hypersensitivity reaction: I.M., SubQ: 0.3-0.5 mg every 15-20 minutes if condition requires; if hypotension is present: 0.1 mg I.V. slowly over 5-10 minutes followed by continuous infusion 1-10 mcg/minute
Symptomatic bradycardia or heart block (not responsive to atropine or pacing): I.V. infusion: 1-10 mcg/minute; titrate to desired effect
Refractory hypotension (refractory to dopamine/dobutamine): Continuous I.V. infusion 1 mcg/minute (range: 1-10 mcg/minute); titrate dosage to desired effect; severe cardiac dysfunction may require doses >10 mcg/minute (up to 0.1 mcg/kg/minute)
Nebulization: Instill 8-15 drops into nebulizer reservoirs; administer 1-3 inhalations 4-6 times/day
Epinephrine can be administered SubQ, I.M., I.V., or intracardiac injection
I.M. administration into the buttocks should be avoided
Preparation of adult I.V. infusion: Dilute 1 mg in 250 mL of D5W or NS (4 mcg/mL); administer at an initial rate of 1 mcg/minute and increase to desired effects; at 20 mcg/minute pure alpha effects occur
Extravasation management: Use phentolamine as antidote. Mix 5 mg with 9 mL of NS. Inject a small amount of this dilution into extravasated area. Blanching should reverse immediately. Monitor site. If blanching should recur, additional injections of phentolamine may be needed.
Oxidation turns drug pink, then a brown color; solutions should not be used if they are discolored or contain a precipitate.
Stability of injection of parenteral admixture at room temperature (25°C) or refrigeration (4°C): 24 hours.
Standard diluent: 1 mg/250 mL NS.
Source: [package insert]