Definition A disorder (OMIM:612518) characterised by defects of cilia.
Cause and effect
• Defective respiratory cilia Respiratory infections and chronic inflammation
• Defective sperm tails Reduced fertility in male patients
• Defective monocilia at the embryonic node Half of patients have left-right body asymmetry and situs inversus (primary ciliary dyskinesia with situs inversus is known as Kartagener syndrome)
Molecular pathology Defects of DNAAF2, which encodes a protein involved in the dynein arm complexes that power cilia, and thus plays a central role in motility, cause ciliary dyskinesia—primary—10.